A Human Study shows the Reversal in Biology of Aging with hyperbaric oxygen therapy (HBOT)

For the First-Time, A Human Study shows the Reversal in Biology of Aging  with Hyperbaric Oxygen Therapy (HBOT)

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TEL AVIV – November 18, 2020: In a scientifically verified approach, signalling an important breakthrough in the study of aging,  Tel Aviv University and The Sagol Center for Hyperbaric Medicine and Research at Shamir Medical Center announced today that, for the first time in humans, two key biological hallmarks of aging, telomere length shortening, and accumulation of senescent cells, can be reversed. The prospective clinical trial, published in peer-reviewed Journal Aging,  utilizes Hyperbaric Oxygen Therapy protocols to demonstrate cellular level improvement in healthy aging adults.

Hyperbaric Oxygen Therapy targets aging as a reversible disease
The prospective clinical trial is part of a comprehensive aging research program taking place in Israel. It was conducted by Prof. Shai Efrati, MD, from the Faculty of Medicine and Sagol School of Neuroscience at Tel Aviv University, and Amir Hadanny, MD, Chief Medical Research Officer of The Sagol Center for Hyperbaric Medicine and Research and co-author of the study. Using a specific protocol of hyperbaric oxygen therapy (HBOT), telomere length was significantly increased and senescent cells were reduced in a population of healthy aging subjects. The study was published in the peer-reviewed journal Aging. Titled: Hyperbaric Oxygen Therapy Increases Telomere Length and Decreases Immunosenescence in Isolated Blood Cells: A Prospective Trial.

A significant breakthrough in the study of aging
The biological deterioration of aging is cited as a major risk factor for cancer, cardiovascular diseases, diabetes, dementia, and Alzheimer’s disease. At the cellular level, two key hallmarks of the aging process are:

The shortening of telomere length of approximately 20-40 bases per year, which is associated with a variety of serious life-threatening illnesses; and The accumulation of senescent cells, the so-called “old malfunctioning cells,” inhibit cell proliferation. The accumulation of senescence contributes to many age-associated conditions and illnesses, while the elimination of those cells can reverse them, as shown in previous animal studies.   

The first study to evaluate telomere length and senescence
This is the first study to evaluate whether hyperbaric oxygen therapy can affect telomere length and senescence using a specific HBOT protocol. The trial included 35 healthy independent adults aged 64 and older. They did not undergo any lifestyle, diet, or medication adjustments.

Hyperbaric Oxygen Therapy How was the study conducted?
Each patient received 60 daily hyperbaric oxygen therapy sessions over the course of 90 days. Whole blood samples were collected prior to treatment, at the 30th and 60th session, and one to two weeks following the last HBOT session, to assess peripheral blood mononuclear cells (PMBCs) telomere length and senescence.

The holy grail of the biology of aging
“After dedicating our HBOT research to exploring its impact on the areas of brain functionality and age-related cognitive decline, we have now uncovered for the first time in humans hyperbaric oxygen therapy’s biological effects at the cellular level in healthy aging adults,” said Prof. Shai Efrati.

 Hyperbaric Oxygen TherapyProfessor Shai Efrati
“Since telomere shortening is considered the ‘Holy Grail’ of the biology of aging, many pharmacological and environmental interventions are being extensively explored in the hopes of enabling telomere elongation.”

Significant improvement of telomere length
“The significant improvement of telomere length shown during and after these unique hyperbaric oxygen therapy protocols provides the scientific community with a new foundation of understanding that aging can, indeed, be targeted and reversed at the basic cellular-biological level.”

Hyperbaric Oxygen Therapy and telomeres | Longevity LIVEImprovement in just three months
Results found that the telomere length of T helper, T cytotoxic, natural killer, and B cells increased significantly. They rose by over 20 percent, following HBOT. The most significant change was in B cells, which increased during the 30th session, 60th session, and post HBOT by:

25.68%±40.42 (p=0.007)
29.39%±23.39 (p=0.0001)
37.63%±52.73 (p=0.007)
In addition, there was a significant decrease in the number of senescent T helpers by -37.30%±33.04 post-HBOT (P<0.0001). T-cytotoxic senescent cell percentages decreased significantly by -10.96%±12.59 (p=0.0004) post-HBOT.

“Until now, interventions such as lifestyle modifications and intense exercise were shown to have some inhibition effect on the expected telomere length shortening,”  explained Dr. Hadanny.

Hyperbaric Oxygen Reverse the aging process!
“However, what is remarkable to note in our study, is that in just three months of hyperbaric oxygen therapy we were able to achieve such significant telomere elongation – at rates far beyond any of the current available interventions or lifestyle modifications.  With this pioneering study, we have opened a door for further research on the prolonged cellular impact of HBOT to reverse the aging process.”

 

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